ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice
Identifieur interne : 000E67 ( Main/Exploration ); précédent : 000E66; suivant : 000E68ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice
Auteurs : Naif Khalaf Alharbi [Royaume-Uni, Arabie saoudite] ; Eriko Padron-Regalado [Royaume-Uni] ; Craig P. Thompson [Royaume-Uni] ; Alexandra Kupke [Allemagne] ; Daniel Wells [Royaume-Uni] ; Megan A. Sloan [Royaume-Uni] ; Keith Grehan [Royaume-Uni] ; Nigel Temperton [Royaume-Uni] ; Teresa Lambe [Royaume-Uni] ; George Warimwe [Royaume-Uni] ; Stephan Becker [Allemagne] ; Adrian V. S. Hill [Royaume-Uni] ; Sarah C. Gilbert [Royaume-Uni]Source :
- Vaccine [ 0264-410X ] ; 2017.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Adenoviridae (immunologie), Animaux, Anticorps antiviraux (biosynthèse), Anticorps antiviraux (immunologie), Anticorps neutralisants (biosynthèse), Anticorps neutralisants (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Immunité cellulaire, Immunité humorale, Immunogénicité des vaccins, Infections à coronavirus (), Infections à coronavirus (immunologie), Relation dose-réponse (immunologie), Souris, Vaccination, Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (immunologie).
- MESH :
- administration et posologie : Vaccins synthétiques.
- biosynthèse : Anticorps antiviraux, Anticorps neutralisants.
- génétique : Adenoviridae, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- immunologie : Adenoviridae, Anticorps antiviraux, Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Vaccins antiviraux, Vaccins synthétiques.
- Animaux, Immunité cellulaire, Immunité humorale, Immunogénicité des vaccins, Infections à coronavirus, Relation dose-réponse (immunologie), Souris, Vaccination.
English descriptors
- KwdEn :
- Adenoviridae (genetics), Adenoviridae (immunology), Animals, Antibodies, Neutralizing (biosynthesis), Antibodies, Neutralizing (immunology), Antibodies, Viral (biosynthesis), Antibodies, Viral (immunology), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Dose-Response Relationship, Immunologic, Immunity, Cellular, Immunity, Humoral, Immunogenicity, Vaccine, Mice, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Vaccination, Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (immunology), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines, Synthetic.
- chemical , biosynthesis : Antibodies, Neutralizing, Antibodies, Viral.
- genetics : Adenoviridae, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- immunology : Adenoviridae, Antibodies, Neutralizing, Antibodies, Viral, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Vaccines, Synthetic, Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Animals, Dose-Response Relationship, Immunologic, Immunity, Cellular, Immunity, Humoral, Immunogenicity, Vaccine, Mice, Vaccination.
Abstract
Inserting tPA leader sequence enhanced humoral responses of ChAdOx1 MERS. ChAdOx1 MERS elicited cellular immunity and neutralising antibodies. ChAdOx1 MERS responses were boosted by MVA MERS. Immunogenicity of a single dose of ChAdOx1 MERS was equivalent to 2 doses of MVA MERS. In MVA, F11 promoter enhanced cellular, but not humoral, immunogenicity, comparing to mH5 promoter.
Url:
DOI: 10.1016/j.vaccine.2017.05.032
PubMed: 28579232
PubMed Central: 5516308
Affiliations:
- Allemagne, Arabie saoudite, Royaume-Uni
- Angleterre, District de Giessen, Hesse (Land), Oxfordshire
- Marbourg, Oxford
- Université d'Oxford
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Le document en format XML
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Thompson</name><affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af015">Department of Zoology, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name><affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea><wicri:noRegion>TTU Emerging Infections</wicri:noRegion><wicri:noRegion>TTU Emerging Infections</wicri:noRegion><wicri:noRegion>TTU Emerging Infections</wicri:noRegion></affiliation></author><author><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name><affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A." last="Sloan">Megan A. Sloan</name><affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name><affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea><wicri:noRegion>Kent ME4 4TB</wicri:noRegion></affiliation></author><author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name><affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea><wicri:noRegion>Kent ME4 4TB</wicri:noRegion></affiliation></author><author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name><affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea><wicri:noRegion>TTU Emerging Infections</wicri:noRegion><wicri:noRegion>TTU Emerging Infections</wicri:noRegion><wicri:noRegion>TTU Emerging Infections</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name><affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name><affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term><term>Adenoviridae (immunology)</term><term>Animals</term><term>Antibodies, Neutralizing (biosynthesis)</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (biosynthesis)</term><term>Antibodies, Viral (immunology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Dose-Response Relationship, Immunologic</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunogenicity, Vaccine</term><term>Mice</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Vaccination</term><term>Vaccines, Synthetic (administration & dosage)</term><term>Vaccines, Synthetic (immunology)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Adenoviridae (immunologie)</term><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps neutralisants (biosynthèse)</term><term>Anticorps neutralisants (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Immunogénicité des vaccins</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (immunologie)</term><term>Relation dose-réponse (immunologie)</term><term>Souris</term><term>Vaccination</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins synthétiques (administration et posologie)</term><term>Vaccins synthétiques (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adenoviridae</term><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Infections à coronavirus</term><term>Vaccins antiviraux</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviridae</term><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccines, Synthetic</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Immunologic</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunogenicity, Vaccine</term><term>Mice</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Immunogénicité des vaccins</term><term>Infections à coronavirus</term><term>Relation dose-réponse (immunologie)</term><term>Souris</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">Inserting tPA leader sequence enhanced humoral responses of ChAdOx1 MERS.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">ChAdOx1 MERS elicited cellular immunity and neutralising antibodies.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">ChAdOx1 MERS responses were boosted by MVA MERS.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">Immunogenicity of a single dose of ChAdOx1 MERS was equivalent to 2 doses of MVA MERS.</p></list-item><list-item id="o0025"><label>•</label><p id="p0025">In MVA, F11 promoter enhanced cellular, but not humoral, immunogenicity, comparing to mH5 promoter.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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Almasri</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Arabie saoudite</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Giessen</li><li>Hesse (Land)</li><li>Oxfordshire</li></region><settlement><li>Marbourg</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name></region><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><name sortKey="Padron Regalado, Eriko" sort="Padron Regalado, Eriko" uniqKey="Padron Regalado E" first="Eriko" last="Padron-Regalado">Eriko Padron-Regalado</name><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A." last="Sloan">Megan A. Sloan</name><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P." last="Thompson">Craig P. Thompson</name><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P." last="Thompson">Craig P. Thompson</name><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name></noRegion></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name></region><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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